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1950\u5e74\u4ee3\uff0c\u79d1\u5b66\u5bb6\u4eec\u5f00\u59cb\u8ba4\u8bc6\u5230\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u5e76\u8bd5\u56fe\u7528\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u7ed8\u5236\u51fa\u8fd9\u79cd\u7ed3\u6784\u3002\u9176\u5b66\u6210\u4e3a\u4e86\u5f53\u65f6\u7684\u70ed\u95e8\u79d1\u5b66\uff0c\u5438\u5f15\u4e86\u4f17\u591a\u50cf\u65bd\u5854\u7279\u66fc\u4e00\u6837\u7684\u4f18\u79c0\u751f\u7269\u5b66\u5bb6\u3002<\/p>\n

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\u4eba\u4f53\u5185\u6709100\u4e07\u4ebf\u4e2a\u7ec6\u80de\uff0c\u7ec6\u83cc\u5219\u662f\u5355\u7ec6\u80de\u6709\u673a\u4f53\uff0c\u7136\u800c\uff0c\u5b87\u5b99\u4e2d\u751f\u547d\u7684\u751f\u7269\u53cd\u5e94\u539f\u7406\u662f\u4e00\u81f4\u7684\u3002\u56e0\u6b64\uff0c\u65bd\u5854\u7279\u66fc\u9009\u62e9\u5bf9\u7ec6\u83cc\u5bf9\u7814\u7a76\u5bf9\u8c61\uff0c\u76ee\u7684\u662f\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u7814\u7a76\u751f\u547d\u4f53\u7684\u751f\u7269\u5316\u5b66\u53cd\u5e94\u3001\u9274\u522b\u51fa\u63a7\u5236\u76f8\u5173\u53cd\u5e94\u7684\u9176\u3002\u8fdb\u4e00\u6b65\uff0c\u901a\u8fc7\u9176\u7684\u7814\u7a76\uff0c\u7814\u7a76\u4eba\u5458\u80fd\u5206\u6790\u5230\u76f8\u5173\u75be\u75c5\u5982\u4f55\u6539\u53d8\u751f\u547d\u4e2d\u76f8\u5e94\u7684\u751f\u7269\u5316\u5b66\u53cd\u5e94\uff0c\u4ece\u800c\u5bfb\u627e\u66f4\u597d\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n

\u201c\u65bd\u5854\u7279\u66fc\u5148\u751f\u4f3c\u4e4e\u5b8c\u5168\u4e0d\u5728\u4e4e\u81ea\u5df1\u6240\u505a\u7814\u7a76\u7684\u5b9e\u9645\u533b\u5b66\u5e94\u7528\uff0c\u4ed6\u81f4\u529b\u4e8e\u63a2\u8ba8\u57fa\u672c\u95ee\u9898\uff0c\u6211\u4e5f\u88ab\u8fd9\u79cd\u57fa\u7840\u7814\u7a76\u6240\u6fc0\u52b1\uff0c\u4f46\u4f5c\u4e3a\u4e00\u540d\u533b\u5b66\u751f\uff0c\u6211\u88ab\u9176\u5728\u533b\u5b66\u4e2d\u7684\u6f5c\u5728\u5e94\u7528\u6240\u6df1\u6df1\u5438\u5f15\u3002\u6211\u770b\u89c1\u65bd\u5854\u7279\u66fc\u7684\u5fae\u751f\u7269\u5b9e\u9a8c\u6b63\u5728\u5960\u5b9a\u73b0\u4ee3\u533b\u5b66\u7684\u751f\u7269\u5316\u5b66\u57fa\u77f3\u3002\u201d<\/p>\n

\u4e0e\u6b64\u540c\u65f6\uff0c\u65bd\u5854\u7279\u66fc\u4e00\u6b65\u6b65\u5c06\u74e6\u6770\u6d1b\u65af\u5f15\u9886\u4e0a\u7814\u7a76\u4e4b\u8def\u3002\u4ed6\u5c06\u81ea\u5df1\u6700\u597d\u7684\u751f\u7269\u5316\u5b66\u6559\u79d1\u4e66\u7ed9\u4e86\u74e6\u6770\u6d1b\u65af\uff0c\u51e0\u4e4e\u6bcf\u5929\u5728\u5b9e\u9a8c\u5ba4\u6307\u5bfc\u4ed6\u7684\u5b9e\u9a8c\uff0c\u8ba8\u8bba\u5b9e\u9a8c\u7ed3\u679c\u548c\u6700\u65b0\u7684\u79d1\u5b66\u53d1\u5c55\u3002<\/p>\n

\u5728\u65bd\u5854\u7279\u66fc\u7684\u5e26\u9886\u4e0b\uff0c\u74e6\u6770\u6d1b\u65af\u5bf9\u8102\u80aa\u5206\u5b50\u4ea7\u751f\u4e86\u6df1\u539a\u5174\u8da3\u3002\u8102\u80aa\u4e3a\u7ec6\u80de\u63d0\u4f9b\u80fd\u91cf\u3001\u50a8\u5b58\u8fc7\u91cf\u7684\u5361\u8def\u91cc\uff0c\u8102\u80aa\u5206\u5b50\u662f\u7ec6\u80de\u819c\u7684\u91cd\u8981\u7ec4\u5206\uff0c\u6c34\u3001\u8425\u517b\u7269\u548c\u4fe1\u53f7\u7b49\u901a\u8fc7\u7ec6\u80de\u819c\u8fdb\u5165\u7ec6\u80de\u5185\u3002\u80c6\u56fa\u9187\u662f\u4e00\u79cd\u8102\u80aa\uff0c\u662f\u6240\u6709\u7ec6\u80de\u819c\u7684\u7ed3\u6784\u90e8\u4ef6\uff0c\u4e5f\u4f1a\u5728\u8840\u6db2\u4e2d\u5faa\u73af\uff0c\u4f46\u662f\u5982\u679c\u5728\u8840\u6db2\u4e2d\u7684\u6d53\u5ea6\u8fc7\u9ad8\uff0c\u5c31\u4f1a\u5f62\u6210\u5bfc\u81f4\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u6591\u5757\u3002<\/p>\n

\u201c\u6211\u7740\u624b\u7814\u7a76\u8102\u80aa\u9178\u7684\u65b0\u9648\u4ee3\u8c22\uff0c\u5f53\u7814\u7a76\u8fdb\u5c55\u5230\u4e00\u5b9a\u7a0b\u5ea6\u65f6\uff0c\u6211\u611f\u89c9\u8fd9\u95e8\u79d1\u5b66\u53ef\u80fd\u4f1a\u5bfc\u81f4\u5bf9\u751f\u7269\u5316\u5b66\u53cd\u5e94\u7684\u4fee\u9970\u2014\u2014\u8fd9\u662f\u7edd\u5927\u591a\u6570\u65b0\u836f\u53d1\u73b0\u7684\u57fa\u7840\u3002\u201d\u74e6\u6770\u6d1b\u65af\u8bf4\u3002<\/p>\n

1957\u5e74\uff0c\u5f53\u74e6\u6770\u6d1b\u65af\u8ba1\u5212\u7ed3\u675f\u5728NIH\u4e24\u5e74\u7684\u5de5\u4f5c\uff0c\u8ba1\u5212\u524d\u5f80\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u65f6\uff0c\u65bd\u5854\u7279\u66fc\u79ef\u6781\u9f13\u52b1\u4ed6\u7559\u5728NIH\uff1a\u201c\u7f57\u4f0a\uff0c\u6211\u8ba4\u4e3a\u4f60\u5df2\u7ecf\u76f8\u5f53\u64c5\u957f\u751f\u7269\u5316\u5b66\u4e86……\u5982\u679c\u4f60\u5728NIH\u505a\u5230\u7b2c\u4e09\u5e74\uff0c\u4f60\u5c06\u5b8c\u5168\u72ec\u7acb\u3002\u201d\u72ec\u7acb\uff0c\u610f\u5473\u7740\u5168\u6743\u8d1f\u8d23\u81ea\u5df1\u5b9e\u9a8c\u7684\u8ba1\u5212\u3001\u89e3\u91ca\u3001\u72ec\u7acb\u53d1\u8868\u8bba\u6587\u2026\u2026<\/p>\n

\u201c\u8fd9\u5c06\u8ba9\u6211\u6210\u4e3a\u4e00\u540d\u751f\u7269\u5316\u5b66\u5bb6\uff0c\u8fd9\u5f88\u6709\u5438\u5f15\u529b\uff1b\u6b64\u5916\uff0c\u6211\u5df2\u6c89\u6d78\u5728\u5bf9\u8102\u8d28\u65b0\u9648\u4ee3\u8c22\u4e2d\u5173\u952e\u9176\u548c\u8f85\u52a9\u9176\u6027\u8d28\u7684\u7814\u7a76\u4e2d\uff0c\u6211\u77e5\u9053\u6709\u4e00\u5929\u6211\u4f1a\u56de\u5230\u533b\u5b66\u9886\u57df\uff0c\u6211\u8bf4\u670d\u81ea\u5df1\uff1a\u5728\u56de\u5230\u533b\u5b66\u9886\u57df\u4e4b\u524d\uff0c\u6211\u5e94\u5f53\u8ba9\u81ea\u5df1\u5728\u751f\u7269\u5316\u5b66\u548c\u9176\u7684\u9886\u57df\u5c3d\u53ef\u80fd\u5f3a\u58ee\u3001\u72ec\u7acb\u3002\u201d<\/p>\n

\u6700\u540e\uff0c\u74e6\u6770\u6d1b\u65af\u9009\u62e9\u7ee7\u7eed\u5728NIH\u5de5\u4f5c\u3002<\/p>\n

\u968f\u540e\uff0c\u65bd\u5854\u7279\u66fc\u7ed9\u4ed6\u5e26\u6765\u4e86\u4e00\u4f4d\u7ec8\u751f\u631a\u53cb\uff1a\u963f\u5c14\u5f17\u96f7\u5fb7\u00b7\u963f\u5c14\u4f2f\u8328\u3002<\/p>\n

\u4e8c\u3001\u7279\u7acb\u72ec\u884c\u7684\u7814\u7a76\u8005<\/strong><\/p>\n

<\/p>\n

\u25ba1959\u5e74\uff0c\u963f\u5c14\u4f2f\u8328\u5728NIH\u5b9e\u9a8c\u5ba4\u3002\u963f\u5c14\u4f2f\u8328\u662f\u65bd\u5854\u7279\u66fc\u5b9e\u9a8c\u5ba4\u7684\u6280\u672f\u5458\uff0c\u6bd4\u74e6\u6770\u6d1b\u65af\u5c0f2\u5c81\uff0c\u4e5f\u662f\u74e6\u6770\u6d1b\u65af\u5728\u56fd\u5bb6\u536b\u751f\u7814\u7a76\u9662\u9047\u5230\u7684\u7b2c\u4e8c\u4f4d\u8d35\u4eba\u3002\u4ed6\u4eec\u4e8c\u4eba\u4ece1959\u5e74\u5f00\u59cb\u5408\u4f5c\uff0c\u6700\u7ec8\u6210\u5c31\u4e86\u4e00\u4e2a\u4f1f\u5927\u7684\u53d1\u660e\uff1a\u6d1b\u4f10\u4ed6\u6c40\u2014\u2014\u4e00\u79cd\u964d\u80c6\u56fa\u9187\u836f\u3002\u56fe\u7247 Merck<\/p>\n

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\u2014\u2014\u74e6\u6770\u6d1b\u65af<\/p>\n

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1931\u5e745\u670816\u65e5\uff0c\u963f\u5c14\u4f2f\u8328\u51fa\u751f\u4e8e\u7ebd\u7ea6\u66fc\u54c8\u987f\u7684\u4e00\u4e2a\u79fb\u6c11\u5bb6\u5ead\u3002\u4ed6\u5728\u5e03\u9c81\u514b\u6797\u6210\u957f\uff0c\u6bd5\u4e1a\u4e8e\u4f0a\u62c9\u739b\u9ad8\u4e2d\u3001\u5e03\u9c81\u514b\u6797\u5b66\u9662\u30021953\u5e74\uff0c\u5728\u9646\u519b\u90e8\u961f\u670d\u5f79\u4e24\u5e74\u540e\uff0c\u5229\u7528\u9000\u4f11\u519b\u4eba\u6743\u5229\u6cd5\u6848\uff08G.I.Bill\uff09\u7684\u8d44\u52a9\uff0c\u963f\u5c14\u4f2f\u8328\u8fdb\u5165\u582a\u8428\u65af\u5927\u5b66\u653b\u8bfb\u535a\u58eb\uff0c\u4e24\u5e74\u540e\u8f6c\u5165\u9a6c\u91cc\u5170\u5927\u5b66\u7ec6\u80de\u751f\u7269\u5b66\u7cfb\uff0c\u7ee7\u7eed\u81ea\u5df1\u7684\u535a\u58eb\u7814\u7a76\u3002\u4e0d\u4e45\uff0c\u4ed6\u7528\u5b8c\u4e86\u8d44\u52a9\u7ecf\u8d39\uff0c\u800c\u5df2\u7ecf\u7ed3\u5a5a\u751f\u5b50\u7684\u4ed6\uff0c\u9700\u8981\u6323\u94b1\u94b1\u517b\u5bb6\u3002<\/p>\n

1959\u5e74\u7684\u4e00\u5929\uff0c\u5728\u4e00\u5802\u751f\u7269\u5316\u5b66\u8bfe\u7ed3\u675f\u540e\uff0c\u65bd\u5854\u7279\u66fc\u6559\u6388\u544a\u8bc9\u4ed6\u7684\u5b66\u751f\uff1a\u201c\u6709\u8c01\u9700\u8981\u4e00\u4efd\u5de5\u4f5c\uff0c\u8bf7\u6765\u627e\u6211\u3002\u201d<\/p>\n

\u963f\u5c14\u4f2f\u8328\u6293\u4f4f\u4e86\u8fd9\u4e2a\u673a\u4f1a\u3002\u4ed6\u5df2\u7ecf\u5b8c\u6210\u535a\u58eb\u8bad\u7ec3\u7684\u6240\u6709\u9879\u76ee\uff0c\u53ea\u9700\u8981\u5199\u4e00\u7bc7\u5b66\u4f4d\u8bba\u6587\uff0c\u4f46\u4ed6\u653e\u5f03\u4e86\u5373\u5c06\u5230\u624b\u7684\u535a\u58eb\u5b66\u4f4d\uff0c\u6210\u4e3aNIH\u7684\u4e00\u4f4d\u5b9e\u9a8c\u5ba4\u6280\u672f\u5458\u3002<\/p>\n

\u963f\u5c14\u4f2f\u8328\u539f\u672c\u671f\u671b\u548c\u81ea\u5df1\u5c0a\u656c\u7684\u6559\u6388\u5171\u540c\u5de5\u4f5c\uff0c\u4f46\u65bd\u5854\u7279\u66fc\u5c06\u4ed6\u5f15\u8350\u7ed9\u74e6\u6770\u6d1b\u65af\u2014\u2014\u65bd\u5854\u7279\u66fc\u8ba4\u4e3a\u74e6\u6770\u6d1b\u65af\u9700\u8981\u4e00\u4e2a\u7814\u7a76\u52a9\u7406\u3002<\/p>\n

\u5408\u4f5c\u4e2d\uff0c\u74e6\u6770\u6d1b\u65af\u5f88\u5feb\u53d1\u73b0\u4e86\u4e24\u4eba\u7684\u5dee\u5f02\u3002<\/p>\n

\u201c\u4e0e\u963f\u5c14\u4f2f\u8328\u76f8\u6bd4\uff0c\u6211\u66f4\u64c5\u957f\u7406\u8bba\uff0c\u800c\u4ed6\u662f\u4e00\u4f4d\u4f1f\u5927\u7684\u5b9e\u9a8c\u5bb6\uff0c\u62e5\u6709\u4e00\u53cc\u7075\u5de7\u7684\u624b\u548c\u516c\u725b\u822c\u7684\u51b3\u5fc3\u3002\u201d<\/p>\n

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\u5f00\u59cb\u65f6\uff0c\u4ed6\u4eec\u4e00\u5757\u5de5\u4f5c\uff0c\u4f46\u5f88\u5feb\u5c31\u5206\u522b\u505a\u540c\u4e00\u5b9e\u9a8c\u7684\u4e0d\u540c\u65b9\u9762\u3002\u201c\u6211\u4eec\u5728\u80fd\u529b\u4e0a\u662f\u4e92\u8865\u7684\uff0c\u6e05\u6668\uff0c\u6211\u89e3\u91ca\u6211\u4eec\u5c06\u8981\u8fdb\u884c\u7684\u5b9e\u9a8c\uff0c\u508d\u665a\u5de5\u4f5c\u7ed3\u675f\u65f6\uff0c\u6211\u4eec\u5bf9\u6bd4\u7ed3\u679c\uff0c\u4ed6\u5b66\u7684\u5f88\u5feb\uff0c\u4e0d\u4e45\u540e\uff0c\u6211\u4eec\u6210\u4e3a\u4eb2\u5bc6\u7684\u5408\u4f5c\u4f19\u4f34\u3002\u201d\u74e6\u6770\u6d1b\u65af\u8bf4\u3002<\/p>\n

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\u5728\u4e24\u4eba\u5c06\u7814\u7a76\u63a8\u8fdb\u65f6\uff0c\u74e6\u6770\u6d1b\u65af\u5efa\u8bae\u963f\u5c14\u4f2f\u8328\u7528\u4e00\u70b9\u65f6\u95f4\u56de\u5230\u9a6c\u91cc\u5170\u5927\u5b66\u5b8c\u6210\u535a\u58eb\u8bba\u6587\uff0c\u4f46\u4ed6\u6d88\u5931\u51e0\u5468\u540e\u53c8\u56de\u5230\u4e86\u5b9e\u9a8c\u5ba4\uff0c\u4ed6\u8868\u793a\u81ea\u5df1\u66f4\u613f\u610f\u505a\u7814\u7a76\u800c\u4e0d\u662f\u5199\u8bba\u6587\u3002<\/p>\n

\u201c\u8fd9\u662f\u6211\u6700\u540e\u4e00\u6b21\u542c\u4ed6\u8c08\u53ca\u81ea\u5df1\u7684\u535a\u58eb\u8bba\u6587\u3002\u6211\u5f00\u59cb\u62c5\u5fc3\uff1a\u4f5c\u4e3a\u4e00\u4e2a\u2018ABD\u2019\uff08All ButDissertation\uff0c\u9664\u535a\u58eb\u8bba\u6587\u5916\uff0c\u5b8c\u6210\u6240\u6709\u535a\u58eb\u8bad\u7ec3\u7684\u4eba\uff09\u4ed6\u7684\u79d1\u5b66\u7814\u7a76\u751f\u6daf\u5982\u4f55\u8fdb\u884c\uff1f\u4e00\u4e2a\u6ca1\u6709\u535a\u58eb\u5b66\u4f4d\u7684\u5353\u8d8a\u7814\u7a76\u8005\uff0c\u4ed6\u7684\u4ef7\u503c\u4f1a\u88ab\u4f4e\u4f30\u3002\u201d\u74e6\u6770\u6d1b\u65af\u5728\u5176\u81ea\u4f20The Moral Corporation: Merck Experiences\u5199\u9053\u3002<\/p>\n

1959\u5e74\uff0c\u74e6\u6770\u6d1b\u65af\u72ec\u7acb\u4e4b\u540e\u7684\u7b2c\u4e00\u7bc7\u8bba\u6587\u8bde\u751f\uff0c\u5c31\u662f\u4e0e\u963f\u5c14\u4f2f\u8328\u5408\u4f5c\u5b8c\u6210\u8bd5\u9a8c\u3002<\/p>\n

\u968f\u7740\u7814\u7a76\u7684\u8fdb\u5c55\uff0c\u74e6\u6770\u6d1b\u65af\u5f00\u59cb\u601d\u8003\uff1a\u5982\u4f55\u5c06\u7ec6\u83cc\u4e2d\u8102\u80aa\u5408\u6210\u7684\u7814\u7a76\u4e0e\u4eba\u4f53\u8054\u7cfb\u8d77\u3002<\/p>\n

\u201c\u65bd\u5854\u7279\u66fc\u662f\u4e00\u4e2a\u7eaf\u7cb9\u4e3b\u4e49\u8005\uff0c\u53ea\u5173\u5fc3\u4ed6\u7684\u5fae\u751f\u7269\u79d1\u5b66\uff0c\u4f46\u6211\u7684\u533b\u5b66\u8bad\u7ec3\u8ba9\u6211\u76f8\u4fe1\uff1a\u6211\u4eec\u5bf9\u7ec6\u83cc\u9176\u7684\u7814\u7a76\u4e5f\u53ef\u7528\u4e8e\u89e3\u91ca\u80c6\u56fa\u9187\u5728\u4eba\u4f53\u5185\u7684\u5408\u6210\u3002\u5f53\u65bd\u5854\u7279\u66fc\u2018\u56db\u4e24\u62d4\u5343\u91d1\u2019\uff0c\u5f15\u5bfc\u6211\u6539\u53d8\u751f\u547d\u65b9\u5411\u65f6\uff0c\u80c6\u56fa\u9187\u5df2\u7ecf\u94ed\u523b\u5728\u6211\u8111\u6d77\uff0c\u6210\u4e3a\u6211\u672a\u6765\u7814\u7a76\u7684\u6f5c\u5728\u9776\u6807\u3002\u201d<\/p>\n

1966\u5e74\uff0c\u5728NIH\u5de5\u4f5c\u5341\u5e74\u540e\uff0c\u74e6\u6770\u6d1b\u65af\u5e94\u9080\u51fa\u4efb\u534e\u76db\u987f\u5927\u5b66\u751f\u7269\u5316\u5b66\u7cfb\u4e3b\u4efb\u3002<\/p>\n

\u963f\u5c14\u4f2f\u8328\u8981\u6c42\u540c\u884c\uff0c\u4f46\u74e6\u6770\u6d1b\u65af\u8b66\u544a\u4ed6\uff0c\u4ed6\u4ecd\u672a\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff0c\u800c\u535a\u58eb\u5b66\u4f4d\u5728\u4e00\u6240\u7814\u7a76\u578b\u5927\u5b66\u975e\u5e38\u91cd\u8981\uff1b\u53e6\u5916\uff0c\u963f\u5c14\u4f2f\u8328\u5728NIH\u5df2\u7ecf\u83b7\u5f97\u7a33\u5b9a\u804c\u4f4d\u548c\u9876\u7ea7\u85aa\u6c34\uff0c\u5728\u5927\u5b66\u53ef\u80fd\u53ea\u80fd\u5904\u4e8e\u4f4e\u6c34\u5e73\u7684\u804c\u4f4d\u3002<\/p>\n

\u201c\u5230\u534e\u76db\u987f\u5927\u5b66\u4e0d\u662f\u660e\u667a\u4e4b\u4e3e\uff0c\u201d\u8fd9\u662f\u74e6\u6770\u6d1b\u65af\u7684\u5224\u65ad\u3002<\/p>\n

\u963f\u5c14\u4f2f\u8328\u575a\u6301\u4e86\u81ea\u5df1\u7684\u51b3\u5b9a\u3002<\/p>\n

\u4e09\u3001\u80c6\u56fa\u9187\u5fc3\u810f\u75c5<\/strong><\/p>\n

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\u2014\u2014\u74e6\u6770\u6d1b\u65af<\/p>\n

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\u4e0d\u4e45\u4e4b\u540e\uff0c\u7cfb\u91cc\u7684\u6559\u6388\u4eec\u4e00\u81f4\u63a8\u8350\u963f\u5c14\u4f2f\u8328\u7684\u664b\u5347\uff1a\u52a9\u7406\u6559\u6388\u3001\u526f\u6559\u6388\uff08associate professor with tenure\uff0c\u7ec8\u8eab\u6559\u804c\uff09\u3002<\/p>\n

1972\u5e74\uff0c\u745e\u5178\u65af\u5fb7\u54e5\u5c14\u6469\u7684\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u53d1\u73b0\u4e86\u4f4e\u80c6\u56fa\u9187\u996e\u98df\u4e0e\u4f4e\u5fc3\u810f\u75c5\u53d1\u751f\u7387\u4e4b\u95f4\u7684\u7edf\u8ba1\u5b66\u5173\u8054\uff0c\u4f46\u662f\u56e0\u4e3a\u8eab\u4f53\u5185\u53ea\u670925%\u7684\u80c6\u56fa\u9187\u6765\u6e90\u81ea\u996e\u98df\uff0c\u65b0\u53d1\u73b0\u5728\u533b\u5b66\u754c\u5f15\u53d1\u6fc0\u70c8\u4e89\u8bba\u3002<\/p>\n

\u201c\u6211\u5374\u4ece\u672a\u6000\u7591\u8fc7\u5fc3\u810f\u75c5\u4e0e\u80c6\u56fa\u9187\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u6d41\u884c\u75c5\u5b66\u7684\u8bc1\u636e\u662f\u538b\u5012\u6027\u7684\u3002\u4f46\u6211\u77e5\u9053\uff0c\u65e0\u8bba\u7edf\u8ba1\u5b66\u5173\u8054\u5982\u4f55\u5f3a\u5927\uff0c\u6211\u4eec\u5fc5\u987b\u4ece\u5b9e\u9a8c\u4e2d\u627e\u51fa\u76f4\u63a5\u8bc1\u636e\uff0c\u8bc1\u660e\u80c6\u56fa\u9187\u6c34\u5e73\u7684\u964d\u4f4e\u6709\u52a9\u4e8e\u63a7\u5236\u51a0\u5fc3\u75c5\u548c\u5fc3\u810f\u75c5\u60a3\u8005\u7684\u75be\u75c5\u53d1\u5c55\u3002\u201d\u74e6\u6770\u6d1b\u65af\u8bf4\u3002<\/p>\n

\u74e6\u6770\u6d1b\u65af\u5b9e\u9a8c\u5ba4\u7814\u7a76\u76f8\u5173\u7684\u4e09\u6761\u9014\u5f84\uff0c\u4e00\u662f\u6df1\u5165\u4e86\u89e3\u9170\u57fa\u8f7d\u4f53\u86cb\u767d\uff08the acyl carrier protein\uff0cACP\uff09\u7684\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u53d1\u73b0ACP\u4f5c\u4e3a\u86cb\u767d\u8f7d\u4f53\u5728\u7ec6\u80de\u8102\u80aa\u9178\u5408\u6210\u4e2d\u7684\u4e2d\u5fc3\u4f5c\u7528\uff1b\u7b2c\u4e8c\uff0c\u8fdb\u4e00\u6b65\u7cbe\u786e\u5206\u6790\u5404\u79cd\u9176\u5728\u7ec6\u80de\u8102\u80aa\u9178\u5408\u6210\u4e2d\u7684\u4f5c\u7528\uff0c\u4ee5\u4e86\u89e3ACP\u9ad8\u5ea6\u4e13\u4e00\u5316\u7684\u539f\u56e0\uff1b\u7b2c\u4e09\uff0c\u5c3d\u7ba1\u5df2\u7ecf\u77e5\u9053\u7ec6\u80de\u662f\u5982\u4f55\u5efa\u7acb\u8102\u80aa\u9178\u94fe\uff0c\u4f46\u4ecd\u7136\u4e0d\u77e5\u9053\u7684\u662f\uff1aACP\u4e3a\u4ec0\u4e48\u3001\u5982\u4f55\u5728\u8102\u80aa\u9178\u94fe\u7684\u957f\u5ea6\u8fbe\u5230\u4e00\u5b9a\u7a0b\u5ea6\u540e\u4e2d\u6b62\u8fd9\u4e00\u53cd\u5e94\uff1f\u4ed6\u4eec\u9700\u8981\u901a\u8fc7\u201c\u5173\u95ed\u201d\u6bcf\u4e00\u79cd\u9176\u6765\u8bc1\u660e\u5176\u4f5c\u7528\uff0c\u4ee5\u786e\u5b9a\u7ec6\u80de\u8102\u80aa\u9178\u5408\u6210\u673a\u5236\u3002<\/p>\n

1971\u5e74\uff0c\u74e6\u6770\u6d1b\u65af\u5728\u5176\u4f20\u7eaa\u4e2d\u5199\u9053\uff0c\u4ed6\u4eec\u8ddd\u79bb\u5168\u9762\u7406\u89e3\u7ec6\u80de\u8102\u80aa\u9178\u53cd\u5e94\u7684\u751f\u7269\u5316\u5b66\u8fc7\u7a0b\u53ea\u6709\u4e00\u6b65\u4e4b\u9065\u3002<\/p>\n

\u4e0e\u6b64\u540c\u65f6\uff0c\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u53d1\u73b0\uff1a\u65e5\u672c\u4eba\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u6b7b\u4ea1\u7387\u975e\u5e38\u4f4e\uff0c\u4ed6\u4eec\u8840\u6db2\u4e2d\u7684\u80c6\u56fa\u9187\u6c34\u5e73\u5f88\u4f4e\uff0c\u4e0e\u6b64\u76f8\u53cd\uff0c\u82ac\u5170\u4eba\u7684\u80c6\u56fa\u9187\u6c34\u5e73\u5f02\u5e38\u9ad8\uff0c\u4ed6\u4eec\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u6b7b\u4ea1\u7387\u662f\u65e5\u672c\u4eba\u768414\u500d\u3002\u4e5f\u5c31\u662f\u8bf4\uff1a\u8840\u6db2\u4e2d\u7684\u80c6\u56fa\u9187\u6c34\u5e73\u662f\u51a0\u5fc3\u75c5\u7684\u91cd\u8981\u8bf1\u56e0\u3002<\/p>\n

1970\u5e74\u4ee3\u521d\uff0c\u79d1\u5b66\u5bb6\u4eec\u7684\u7814\u7a76\u5df2\u663e\u793a\uff0c\u5148\u5929\u6027\u9ad8\u80c6\u56fa\u9187\u6c34\u5e73\u7684\u60a3\u8005\u542b\u6709\u4e00\u79cd\u7f3a\u9677\u57fa\u56e0\uff0c\u4ed6\u4eec\u7684\u809d\u810f\u7f3a\u5931\u67d0\u79cd\u80fd\u5c06\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u8d28\u4ece\u8840\u6db2\u4e2d\u6392\u51fa\u7684\u53d7\u4f53\uff0c\u8840\u6db2\u4e2d\u5f02\u5e38\u9ad8\u6c34\u5e73\u7684\u4f4e\u5bc6\u5ea6\u86cb\u767d\uff0c\u5bfc\u81f4\u51a0\u5fc3\u75c5\u548c\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u65e9\u671f\u6b7b\u4ea1\u3002<\/p>\n

1970\u5e74\u4ee3\u4e2d\u671f\uff0c\u74e6\u6770\u6d1b\u65af\u5b9e\u9a8c\u5ba4\u8fdb\u4e00\u6b65\u7814\u7a76\u5305\u62ec\u80c6\u56fa\u9187\u5728\u5185\u7684\u8102\u8d28\u7684\u5f62\u6210\u548c\u529f\u80fd\u3002<\/p>\n

\u201c\u4e8c\u5341\u591a\u5e74\u7684\u5b9e\u9a8c\u5ba4\u7814\u7a76\uff0c\u6781\u5927\u5730\u63d0\u9ad8\u4e86\u6211\u4eec\u5bf9\u8102\u8d28\u751f\u7269\u5316\u5b66\u8ba4\u8bc6\uff0c\u7279\u522b\u662f\u9176\u3001\u8f85\u9176\u3001\u8fd0\u8f7d\u86cb\u767d\u5728\u7ec6\u80de\u7684\u6b63\u5e38\u548c\u75c5\u7406\u4f5c\u7528\u3002\u6211\u8ba4\u4e3a\uff0c\u5bf9\u9176\u7684\u7814\u7a76\u662f\u8ba4\u8bc6\u75be\u75c5\u7684\u6700\u597d\u9014\u5f84\u3002\u6211\u65e9\u671f\u5bf9\u5fc3\u810f\u75be\u75c5\u7684\u5173\u6ce8\uff0c\u523a\u6fc0\u6211\u7814\u7a76\u9176\u6291\u5236\u5242\u7684\u6f5c\u5728\u4f5c\u7528\uff0c\u4ece\u800c\u5b9e\u9645\u4e0a\u6539\u53d8\u4e86\u75be\u75c5\u7684\u72b6\u6001\u3002\u201d2004\u5e74\uff0c\u74e6\u6770\u6d1b\u65af\u5728\u5176\u81ea\u4f20\u4e2d\u5199\u9053\u3002<\/p>\n

\u56db\u3001\u9ed8\u514b\u5236\u836f\u8f6c\u6298\u70b9<\/strong><\/p>\n

<\/p>\n

\u25baHMG CoA \u8fd8\u539f\u9176\u7684\u53cd\u5e94<\/p>\n

\u6d1b\u4f10\u4ed6\u6c40\uff08lovastatin\uff09\u5206\u5b50\u6a21\u578b<\/p>\n

\u5728\u751f\u7269\u5316\u5b66\u548c\u9176\u5b66\u7684\u9ece\u660e\u65f6\u671f\uff0c\u6211\u5230\u9ed8\u514b\uff0c\u7740\u624b\u5b9e\u65bd\u836f\u7269\u53d1\u73b0\u65b9\u6cd5\u7684\u6218\u7565\u6027\u6539\u53d8\u3002\u5fc3\u8840\u7ba1\u75be\u75c5\u662f\u6211\u7684\u7814\u7a76\u9886\u57df\uff0c\u6211\u66fe\u5728\u57fa\u7840\u79d1\u5b66\u65b9\u9762\u505a\u51fa\u8fc7\u91cd\u8981\u8d21\u732e\uff0c\u5728\u5ba3\u8bb2\u4e0e\u6307\u5bfc\u4e4b\u5916\uff0c\u9700\u8981\u6709\u5b9e\u8df5\u8bc1\u660e\uff0c\u6211\u80fd\u5426\u5411\u9ed8\u514b\u5c55\u793a\uff1a\u5982\u4f55\u5c06\u5fae\u751f\u7269\u7684\u751f\u7269\u5408\u6210\u77e5\u8bc6\u8f6c\u5316\u4e3a\u65b0\u836f\u53d1\u73b0\uff1f<\/p>\n

\u963f\u5c14\u4f2f\u8328\u518d\u6b21\u52a9\u6211\u4e00\u81c2\u4e4b\u529b\u3002<\/p>\n

\u2014\u2014\u74e6\u6770\u6d1b\u65af<\/p>\n

\u9ed8\u514b\u7684\u7814\u7a76\u5f00\u53d1\u90e8\u662f\u4e00\u4e2a\u5e9e\u5927\u673a\u6784\uff0c1975\u5e74\u5ea6\u7684\u9884\u7b97\u4e3a1.25\u4ebf\u7f8e\u5143\uff0c\u7814\u53d1\u4eba\u54581800\u591a\u4eba\u30021975\u5e74\uff0c\u9ed8\u514b\u8fce\u63a5\u533b\u5b66\u79d1\u5b66\u7684\u53d8\u5316\uff0c\u5f15\u8fdb\u4e86\u5305\u62ec\u74e6\u6770\u6d1b\u65af\u3001\u963f\u5c14\u4f2f\u8328\u5728\u5185\u7684\u751f\u7269\u5316\u5b66\u5bb6\u3002<\/p>\n

1974\u5e7411\u6708\uff0c\u9ed8\u514b\u9080\u8bf7\u74e6\u6770\u6d1b\u65af\u51fa\u4efb\u57fa\u7840\u7814\u7a76\u90e8\u8d1f\u8d23\u4eba\uff0c\u4e00\u5e74\u540e\u4efb\u7814\u7a76\u90e8\u8d1f\u8d23\u4eba\uff0c\u5e76\u627f\u8bfa\u4e3a\u4ed6\u5efa\u4e00\u5e62\u5316\u5b66\u5927\u697c\u3002<\/p>\n

\u963f\u5c14\u4f2f\u8328\u518d\u6b21\u8981\u6c42\u8ddf\u968f\u4ed6\u5230\u9ed8\u514b\u3002\u74e6\u6770\u6d1b\u65af\u8b66\u544a\uff1a\u6ca1\u6709\u535a\u58eb\u5b66\u4f4d\u7684\u4ed6\u5df2\u7ecf\u5728\u5927\u5b66\u6709\u4e00\u4e2a\u7a33\u5b9a\u804c\u4f4d\uff0c\u5230\u9ed8\u514b\u7684\u524d\u9014\u5374\u6ca1\u6709\u4fdd\u969c\u3002\u518d\u4e00\u6b21\uff0c\u963f\u5c14\u4f2f\u8328\u9009\u62e9\u8ffd\u968f\u74e6\u6770\u6d1b\u65af\u5230\u603b\u90e8\u4f4d\u4e8e\u65b0\u6cfd\u897f\u5dde\u7684\u9ed8\u514b\u3002<\/p>\n

\u4ece\u534e\u76db\u987f\u5927\u5b66\u5230\u9ed8\u514b\u5236\u836f\uff0c\u4e0d\u4ec5\u6210\u4e3a\u4e24\u4eba\u751f\u547d\u4e2d\u65b0\u7684\u8f6c\u6298\u70b9\uff0c\u4e5f\u9769\u547d\u5316\u4e86\u9ed8\u514b\u5236\u836f\u3001\u4eba\u7c7b\u65b0\u836f\u7814\u5236\u7684\u65b9\u6cd5\u2014\u2014\u9776\u5411\u5206\u5b50\u5236\u836f\u3002<\/p>\n

<\/p>\n

<\/p>\n

\u25ba1985\u5e74\uff0c\u7f8e\u56fd\u79d1\u5b66\u5bb6\u9ea6\u53ef\u00b7\u5e03\u6717\uff08 Michael S. Brown\uff0c\u5de6\uff09\u548c\u7ea6\u745f\u592b\u00b7\u91cc\u6b27\u7eb3\u5fb7\u00b7\u6208\u5c14\u8328\u5766\uff08Joseph L.Goldstein\uff0c\u53f3\uff09\u201c\u56e0\u5728\u80c6\u56fa\u9187\u4ee3\u8c22\u7684\u8c03\u63a7\u65b9\u9762\u7684\u53d1\u73b0\u201d\uff0c\u5171\u4eab\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/p>\n

1960\u5e74\u4ee3\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff1a\u80c6\u56fa\u9187\u751f\u7269\u5408\u6210\u4e2d\u4e00\u79cd\u7279\u522b\u7684\u9176\u2014\u2014HMG-CoA\u8fd8\u539f\u9176\uff0c\u8c03\u63a7\u4e86\u7ec6\u80de\u4e2d\u80c6\u56fa\u9187\u7684\u751f\u6210\u91cf\uff0c\u8fd9\u4e00\u5de5\u4f5c\u4e3a\u9ea6\u53ef\u00b7\u5e03\u6717\u548c\u7ea6\u745f\u592b\u00b7\u91cc\u6b27\u7eb3\u5fb7\u00b7\u6208\u5c14\u8328\u5766\u4e24\u4f4d\u79d1\u5b66\u5bb6\u8d62\u5f97\u4e861985\u5e74\u7684\u8bfa\u8d1d\u5c14\u5956\u3002<\/p>\n

\u533b\u5b66\u7814\u7a76\u4eba\u5458\u9762\u4e34\u7684\u65b0\u6311\u6218\u662f\uff1a\u80fd\u5426\u5bfb\u627e\u5230\u4e00\u79cd\u5316\u5408\u7269\uff0c\u786e\u4fdd\u7531\u5b83\u7814\u5236\u51fa\u7684\u836f\u7269\u5bf9\u4eba\u7c7b\u5b89\u5168\u3002<\/p>\n

\u8bb8\u591a\u7814\u7a76\u4eba\u5458\u58f0\u79f0\u6210\u529f\u5728\u5373\uff0c\u6700\u540e\u529f\u4e8f\u4e00\u7bd1\u3002<\/p>\n

1975\u5e74\uff0c\u74e6\u6770\u6d1b\u65af\u535a\u58eb\u51fa\u4efb\u9ed8\u514b\u7814\u7a76\u5f00\u53d1\u90e8\u8d1f\u8d23\u4eba\u65f6\uff0c\u5efa\u8bae\u963f\u5c14\u4f2f\u8328\u653b\u5173\u8fd9\u4e00\u96be\u9898\uff1a\u5bfb\u627e\u6291\u5236HMG-CoA\u8fd8\u539f\u9176\u7684\u5316\u5408\u7269\uff0c\u5e76\u5c06\u4e4b\u7814\u5236\u6210\u836f\u7269\u3002<\/p>\n

\u5728\u9ed8\u514b\u5b9e\u9a8c\u5ba4\u57fa\u7840\u90e8\uff0c\u4e00\u9879\u6709\u5173\u80c6\u56fa\u9187\u7684\u7814\u7a76\u5f15\u8d77\u74e6\u6770\u6d1b\u65af\u7684\u6ce8\u610f\u3002\u5f53\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7b5b\u9009\uff0c\u53d1\u73b0\u4e00\u79cd\u540d\u4e3a\u964d\u8102\u9170\u80fa\uff08halofenate\uff09\u7684\u5316\u5408\u7269\u80fd\u964d\u4f4e\u8840\u6db2\u4e2d\u7684\u80c6\u56fa\u9187\uff0c\u5e76\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u4ed6\u4eec\u77e5\u5176\u7136\uff0c\u4e0d\u77e5\u5176\u6240\u4ee5\u7136\uff0c\u5373\u5c1a\u672a\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u4e86\u89e3\u5230\u8fd9\u79cd\u5316\u5408\u7269\u5de5\u4f5c\u673a\u7406\uff0c\u751a\u81f3\u4e0d\u77e5\u9053\u8fd9\u79cd\u5316\u5408\u7269\u662f\u6291\u5236\u4e86\u54ea\u4e00\u79cd\u9176\u3002<\/p>\n

\u63a7\u5236\u80c6\u56fa\u9187\u7684\u5408\u6210\u5f88\u91cd\u8981\uff0c\u56e0\u4e3a\u4eba\u4f53\u4e2d\u4e09\u5206\u4e4b\u4e8c\u5230\u56db\u5206\u4e4b\u4e09\u7684\u80c6\u56fa\u9187\u662f\u8eab\u4f53\u5185\u90e8\u4ea7\u751f\u7684\uff0c\u5176\u4f59\u90e8\u5206\u6765\u81ea\u996e\u98df\u3002\u975e\u6b63\u5e38\u9ad8\u6c34\u5e73\u7684\u80c6\u56fa\u9187\u4f1a\u5bfc\u81f4\u8102\u80aa\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u51dd\u7ed3\u6210\u6591\u5757\uff0c\u5f15\u53d1\u51a0\u5fc3\u75c5\u548c\u5fc3\u810f\u75c5\u3002\u57281970\u5e74\u4ee3\uff0c\u533b\u751f\u4eec\u5c06\u996e\u98df\u8c03\u7406\u4f5c\u4e3a\u964d\u4f4e\u80c6\u56fa\u9187\u7684\u4e3b\u8981\u65b9\u6cd5\uff0c\u4f46\u8fd9\u79cd\u65b9\u6cd5\u5f88\u96be\u5bfc\u81f4\u80c6\u56fa\u9187\u6c34\u5e73\u7684\u660e\u663e\u4e0b\u964d\uff0c\u533b\u751f\u548c\u60a3\u8005\u5747\u9700\u8981\u4e00\u79cd\u6709\u6548\u65b9\u6cd5\u6291\u5236\u4f53\u5185\u80c6\u56fa\u9187\u7684\u4ea7\u751f\u3002<\/p>\n

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\u5728NIH\u505a\u7814\u7a76\u65f6\uff0c\u74e6\u6770\u6d1b\u65af\u5df2\u76f8\u4fe1\u9776\u5411\u7279\u5b9a\u9176\u5e94\u8be5\u662f\u66f4\u6709\u6548\u7684\u836f\u7269\u53d1\u73b0\u65b9\u6cd5\u3002<\/p>\n

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\u201c\u8fd9\u79cd\u65b9\u6cd5\u4e0d\u662f\u6211\u53d1\u660e\u7684\uff0c\u6cbb\u7597\u9ad8\u8840\u538b\u7684 \u03b2\u53d7\u4f53\u963b\u65ad\u836f\u5c31\u662f\u901a\u8fc7\u9776\u5411\u7279\u5b9a\u7684\u5206\u5b50\u53d7\u4f53\u800c\u53d1\u660e\u7684\u3002\u4f46\u6ca1\u6709\u5b9e\u9a8c\u5ba4\u5c06\u8fd9\u79cd\u65b9\u6cd5\u4f5c\u4e3a\u65b0\u6218\u7565\u65b9\u6cd5\u5b9e\u65bd\u3002\u201d<\/p>\n

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<\/p>\n

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\u5f53\u4ed6\u4eec\u5168\u529b\u5bfb\u627e\u76ee\u6807\u6291\u5236\u5242\u65f6\uff0c\u4f20\u6765\u6d88\u606f\uff1a\u65e5\u672c\u201c\u4e09\u5171\u201d\uff08Sankyo Co\uff09\u5236\u836f\u516c\u53f8\u79d1\u5b66\u5bb6\u8fdc\u85e4\u7ae0\uff08Akira Endo\uff09\u62a5\u544a\u4e86\u4e00\u79cd\u540d\u4e3a\u5eb7\u5e15\u4e01\uff08compactin\uff09\u5316\u5408\u7269\uff0c\u80fd\u591f\u6291\u5236 (HMG-GoA\uff09\u8fd8\u539f\u5242\u3002\u6839\u636e\u6b64\u62a5\u544a\uff0c\u201c\u4e09\u5171\u201d\u751f\u4ea7\u4e86\u4e00\u79cd\u53ef\u53e3\u670d\u7684\u81ea\u7136\u4ea7\u54c1\u3002\u4ed6\u4eec\u88ab\u8fd9\u4e00\u65b0\u95fb\u6240\u6fc0\u52b1\u4e86\uff0c\u4f46\u4e5f\u5f88\u7d27\u5f20\uff0c\u56e0\u4e3a\u8fd9\u662f\u7ade\u4e89\u3002<\/p>\n

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\u795e\u5947\u65f6\u523b\u7ec8\u4e8e\u6765\u4e34\u30021978\u5e74\u7684\u4e00\u5929\uff0c\u5728\u626b\u63cf\u4e86\u6570\u5343\u4e2a\u571f\u58e4\u5fae\u751f\u7269\u6837\u54c1\u540e\uff0c\u7a81\u7136\u95f4\uff0c\u963f\u5c14\u4f2f\u8328\u56e2\u961f\u5f97\u5230\u4e86\u4ed6\u4eec\u7684\u76ee\u6807\u4ea7\u7269\uff1a\u7f16\u53f7\u4e3a18\u7684\u571f\u58e4\u6837\u54c1\u2014\u2014\u571f\u66f2\u9709\uff0c\u80fd\u4ea7\u751f\u6291\u5236\u9776\u5411\u9176\u7684\u6d3b\u6027\u5242\u3002<\/p>\n

\u201c\u4f46\u662f\uff0c\u5728\u5316\u5b66\u5bb6\u7eaf\u5316\u51fa\u6d3b\u6027\u7269\u8d28\u3001\u786e\u5b9a\u5176\u5316\u5b66\u7ed3\u6784\u4e4b\u524d\uff0c\u6211\u4eec\u5c1a\u4e0d\u80fd\u786e\u5b9a\u53d1\u73b0\u7269\u662f\u5426\u7b49\u540c\u4e8e\u2018\u4e09\u5171\u2019\u7684\u2018\u5eb7\u5e15\u4e01\u2019\u3002\u7ed3\u679c\u663e\u793a\uff0c\u6211\u4eec\u7684Mevacor\uff08\u5546\u54c1\u540d\uff1aLovastatin\uff0c\u6d1b\u4f10\u4ed6\u6c40\uff09\u867d\u7136\u5728\u7ed3\u6784\u4e0a\u7c7b\u4f3c\u2018\u5eb7\u5e15\u4e01\u2019\uff0c\u4f46\u5b83\u5374\u662f\u4e00\u4e2a\u5168\u65b0\u7684\u5316\u5408\u7269\u3002\u201d<\/p>\n

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\"\u6d1b\u4f10\u4ed6\u6c40(lovastatin)\u5206\u5b50\u6a21\u578b\"<\/p>\n

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1980\u5e749\u6708\uff0c\u65b0\u6cfd\u897f\u7684\u4e00\u4e2a\u6d77\u8fb9\u6e21\u5047\u6751\uff0c\u9ed8\u514b\u7814\u53d1\u90e8\u4e3e\u884c\u4e3a\u671f\u56db\u5929\u7684\u5e74\u5ea6\u4f1a\u8bae\uff0c\u8ba8\u8bba\u8fc7\u53bb\u4e00\u5e74\u7684\u5de5\u4f5c\u4ee5\u53ca\u672a\u6765\u7684\u8ba1\u5212\u3002\u4f1a\u8bae\u671f\u95f4\uff0c\u4e00\u4e2a\u6765\u81ea\u65e5\u672c\u7684\u7535\u8bdd\u4ee4\u74e6\u6770\u6d1b\u65af\u60ca\u9a87\u3002<\/p>\n

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\u8fd9\u662f\u4e00\u4e2a\u4ece\u5929\u800c\u964d\u7684\u6bc1\u706d\u6027\u6d88\u606f\u3002<\/p>\n

\u201c\u6211\u4eec\u77e5\u9053\u2018\u5eb7\u67cf\u6c40\u2019\u548c\u2018\u6d1b\u4f10\u4ed6\u6c40\u2019\u7684\u5de5\u4f5c\u673a\u7406\u662f\u4e00\u81f4\u7684\uff1a\u963b\u65ad\u80c6\u56fa\u9187\u5408\u6210\u7684\u9650\u901f\u9176\u2014\u2014HMG-CoA\u8fd8\u539f\u9176\u3002\u5982\u679c\u5eb7\u67cf\u6c40\u56e0\u6b64\u7279\u522b\u7ed3\u6784\u800c\u5f15\u53d1\u80bf\u7624\uff0c\u90a3\u4e48\u6d1b\u4f10\u4ed6\u6c40\u53ef\u80fd\u4e0d\u4f1a\u6709\u6bd2\u6027\uff0c\u56e0\u4e3a\u4e8c\u8005\u5728\u7ed3\u6784\u4e0a\u6709\u5dee\u522b\uff1b\u4f46\u5982\u679c\u5eb7\u67cf\u6c40\u662f\u901a\u8fc7\u6291\u5236\u9650\u901f\u9176\u7684\u6d3b\u6027\u4f4d\u70b9\u800c\u5f15\u53d1\u80bf\u7624\uff0c\u90a3\u4e48\u6240\u6709\u6291\u5236\u8fd9\u79cd\u9176\u7684\u836f\u7269\u53ef\u80fd\u5177\u6709\u540c\u6837\u7684\u6bd2\u6027\u3002\u6211\u4eec\u6ca1\u6709\u529e\u6cd5\u4e86\u89e3\u5eb7\u67cf\u6c40\u7a76\u7adf\u662f\u901a\u8fc7\u54ea\u79cd\u9014\u5f84\u5f15\u53d1\u80bf\u7624\u3002\u6211\u4eec\u53ea\u77e5\u9053\u2018\u4e09\u5171\u2019\u505c\u6b62\u4e86\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8fd9\u610f\u5473\u7740\u2018\u5eb7\u67cf\u6c40\u2019\u2014\u2014\u53ef\u80fd\u4e5f\u5305\u62ec\u2018\u6d1b\u4f10\u4ed6\u6c40\u2019\u2014\u2014\u5f15\u53d1\u4e86\u4e25\u91cd\u95ee\u9898\u3002\u201d<\/p>\n

\u98ce\u4e91\u7a81\u53d8\u4e4b\u9645\uff0c\u74e6\u6770\u6d1b\u65af\u51b3\u5b9a\uff1a\u9ed8\u514b\u7acb\u5373\u505c\u6b62\u6d1b\u4f10\u4ed6\u6c40\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u201c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u8270\u96be\u7684\u51b3\u5b9a\u3002\u6211\u4eec\u77e5\u9053\uff0c\u5c3d\u7ba1\u5df2\u5b8c\u6210\u7684\u8bd5\u9a8c\u6ca1\u6709\u663e\u793a\u4e86\u6d1b\u4f10\u4ed6\u6c40\u4f1a\u5f15\u53d1\u80bf\u7624\u548c\u5176\u5b83\u526f\u4f5c\u7528\uff0c\u4f46\u9ed8\u514b\u5e76\u672a\u5b8c\u6210\u957f\u671f\u4e34\u5e8a\u6bd2\u7406\u8bd5\u9a8c\uff0c\u4e00\u56e2\u4e4c\u4e91\u7b3c\u7f69\u5728\u6211\u4eec\u5934\u4e0a\u2026\u2026\u6211\u548c\u540c\u4e8b\u4eec\u5c0f\u5fc3\u7ffc\u7ffc\u5730\u8ba8\u8bba\u8fd9\u4e2a\u95ee\u9898\uff0c\u4f46\u4e2d\u6b62\u8bd5\u9a8c\u7684\u51b3\u5b9a\u662f\u6211\u4e2a\u4eba\u505a\u51fa\u7684\uff0c\u6211\u4e0d\u9700\u8981\u4efb\u4f55\u5efa\u8bae\u3002\u6211\u4eec\u4e0d\u5141\u8bb8\u4efb\u4f55\u4eba\u4f7f\u7528\u5373\u4f7f\u662f\u53ef\u80fd\u5bfc\u81f4\u6700\u8f7b\u5fae\u764c\u75c7\u7684\u836f\u7269\u3002\u4e00\u4e2a\u672a\u786e\u8bc1\u7684\u6d88\u606f\u4e5f\u8db3\u4ee5\u8ba9\u6211\u505a\u51fa\u8fd9\u4e2a\u51b3\u5b9a\u2026\u2026\u201d<\/p>\n

\u74e6\u6770\u6d1b\u65af\u5411\u65f6\u4efb\u9ed8\u514b\u603b\u88c1\u548c\u9996\u5e2d\u6267\u884c\u5b98\u7ea6\u7ff0\u00b7\u970d\u5170\uff08John Horan\uff09\u62a5\u544a\u4e86\u4ed6\u7684\u51b3\u5b9a\u3002\u201c\u4ed6\u7406\u89e3\u8fd9\u4e2a\u95ee\u9898\u7684\u610f\u4e49\uff0c\u8868\u793a\u6211\u4eec\u9664\u4e86\u505c\u6b62\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u5916\uff0c\u53e6\u65e0\u9009\u62e9\uff0c\u4ed6\u8981\u6c42\u6211\u968f\u65f6\u544a\u77e5\u4e8b\u60c5\u7684\u8fdb\u5c55\u3002\u201d<\/p>\n

\u74e6\u6770\u6d1b\u65af\u53ec\u5f00\u7d27\u6025\u4f1a\u8bae\uff0c\u8fbe\u6210\u4e09\u4e2a\u5171\u8bc6\uff1a\u4e00\u3001\u7acb\u5373\u505c\u6b62\u6d1b\u4f10\u4ed6\u6c40\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u4e8c\u3001\u5e94\u8be5\u544a\u77e5FDA\uff1b\u7b2c\u4e09\u3001\u52aa\u529b\u76f4\u63a5\u4ece\u65e5\u672c\u201c\u4e09\u5171\u201d\u83b7\u5f97\u66f4\u591a\u4fe1\u606f\u3002<\/p>\n

\u201c\u6211\u4eec\u53cd\u7701\u81ea\u5df1\u7684\u7814\u7a76\uff1a\u6211\u4eec\u5728\u5b89\u5168\u6027\u548c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6ca1\u6709\u770b\u89c1\u6d1b\u4f10\u4ed6\u6c40\u5f15\u53d1\u80bf\u7624\u7b49\u526f\u4f5c\u7528\u7684\u8bc1\u636e\uff0c\u4f46\u6211\u4eec\u7684\u7814\u7a76\u65f6\u95f4\u6bd4\u8f83\u77ed\uff0c\u65e5\u672c\u4e09\u5171\u7684\u4fe1\u606f\u4ee4\u6211\u4eec\u62c5\u5fc3\uff0c\u6211\u4eec\u5e94\u8be5\u600e\u4e48\u529e\uff1f\u201d\u74e6\u6770\u6d1b\u65af\u56de\u5fc6\u9053\uff0c\u4f1a\u8bae\u4e2d\uff0c\u4e00\u4f4d\u4e34\u5e8a\u7ba1\u7406\u4e13\u5bb6\u56e0\u8fc7\u4e8e\u9707\u60ca\u800c\u4e0d\u80fd\u8a00\u8bed\u3002<\/p>\n

\u74e6\u6770\u6d1b\u65af\u51b3\u5b9a\u4eb2\u81ea\u4e86\u89e3\u65e5\u672c\u201c\u4e09\u5171\u201d\u60c5\u51b5\u3002\u4f46\u5728\u6b64\u4e4b\u524d\uff0c\u4ed6\u6253\u4e00\u4e2a\u66f4\u4e3a\u8270\u96be\u7684\u7535\u8bdd\uff0c\u544a\u77e5\u963f\u5c14\u4f2f\u8328\u3002<\/p>\n

\u201c\u8fd9\u4e2a\u7535\u8bdd\u5bf9\u4ed6\uff08\u963f\u5c14\u5f17\u96f7\u5fb7\uff09\u7684\u6253\u51fb\u592a\u5927\uff0c\u4ed6\u751a\u81f3\u60f3\u8981\u79bb\u5f00\u9ed8\u514b\u3002\u201d \u5728\u300a\u7ebd\u7ea6\u65f6\u62a5\u300b\u7684\u91c7\u8bbf\u4e2d\uff0c\u963f\u5c14\u4f2f\u8328\u592a\u592a\u56de\u5fc6\u8bf4\u3002<\/p>\n

\u74e6\u6770\u6d1b\u65af\u9f13\u52b1\u963f\u5c14\u4f2f\u8328\uff1a\u201c\u6211\u4eec\u4f1a\u5728\u5b89\u5168\u7814\u7a76\u65b9\u6cd5\u505a\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\uff0c\u4f46\u95ee\u9898\u662f\u5b58\u5728\u7684\uff0c\u6211\u4eec\u9700\u8981\u5047\u8bbe\u6d1b\u4f10\u4ed6\u6c40\u5df2\u6b7b\uff0c\u9700\u8981\u518d\u53d1\u73b0\u53e6\u4e00\u4e2a\u65b0\u7684\u5019\u9009\u836f\u7269\u2026\u2026\u8ba9\u6211\u4eec\u91cd\u65b0\u5f00\u59cb\uff0c\u53d1\u73b0\u53e6\u4e00\u4e2a\u65b0\u5206\u5b50\u5427\uff0c\u4e00\u4e2a\u4e0e\u5eb7\u67cf\u6c40\u7ed3\u6784\u4e0d\u540c\u3001\u4e0d\u4f1a\u5f15\u53d1\u7c7b\u4f3c\u6bd2\u6027\u7684\u65b0\u5206\u5b50\u3002\u201d<\/p>\n

1980\u5e74\u7684\u51ac\u5929\uff0c\u5bf9\u74e6\u6770\u6d1b\u65af\u548c\u963f\u5c14\u4f2f\u8328\u6765\u8bf4\uff0c\u5f02\u5e38\u8270\u96be\u3002\u4ed6\u4eec\u4e00\u65b9\u9762\u7ee7\u7eed\u6d1b\u4f10\u4ed6\u6c40\u7684\u7814\u7a76\uff0c\u6bd2\u7406\u5b9e\u9a8c\u4ecd\u7136\u6ca1\u6709\u8bc1\u636e\u663e\u793a\u7c7b\u4f3c\u4e8e\u65e5\u672c\u65b9\u9762\u7684\u6bd2\u6027\uff0c\u4f46\u4ecd\u9700\u8981\u957f\u671f\u7684\u5b9e\u9a8c\u7ed3\u679c\uff1b\u4e0e\u6b64\u540c\u65f6\uff0c\u5b9e\u9a8c\u5ba4\u5c06\u8d44\u6e90\u66f4\u591a\u5730\u6295\u5165\u5230\u5bfb\u627e\u65b0\u5206\u5b50\u7684\u9879\u76ee\u4e0a\u3002<\/p>\n

1981\u5e74\uff0c\u74e6\u6770\u6d1b\u65af\u80a9\u4e0a\u7684\u8d23\u4efb\u66f4\u91cd\u4e86\uff1a\u9ed8\u514b\u8463\u4e8b\u4f1a\u4efb\u547d\u4ed6\u4e3a\u516c\u53f8\u9ad8\u7ea7\u526f\u603b\u88c1\uff0c\u8d1f\u8d23\u516c\u53f8\u7684\u7814\u7a76\u6218\u7565\u89c4\u5212\u3002\u4f46\u6d1b\u4f10\u4ed6\u6c40\u4ecd\u662f\u4ed6\u5fc3\u4e2d\u6c89\u91cd\u7684\u7275\u6302\uff1a\u201c\u4eceNIH\u5f00\u59cb\uff0c\u6211\u5728\u8fd9\u4e2a\u9879\u76ee\u4e0a\u7814\u7a76\u4e8625\u5e74\uff0c\u6211\u51b3\u5b9a\u5f04\u6e05\u695a\u7a76\u7adf\u662f\u600e\u4e48\u4f1a\u4e8b\u3002\u201d<\/p>\n

\u4ed6\u81f4\u4fe1\u65e5\u672c\u516c\u53f8\uff0c\u5e0c\u671b\u4ed6\u4eec\u5206\u4eab\u5b89\u5168\u8bd5\u9a8c\u7684\u8bc4\u4f30\u7ed3\u679c\u3002\u6ca1\u6709\u6536\u5230\u56de\u590d\u540e\uff0c\u4ed6\u6253\u7535\u8bdd\u8be2\u95ee\uff1a\u201c\u6211\u4eec\u6709\u4e00\u4e2a\u7c7b\u4f3c\u4e8eHMG-CoA\u8fd8\u539f\u9176\u7684\u6291\u5236\u5242\uff0c\u6211\u5e0c\u671b\u4e86\u89e3\u4f60\u4eec\u7684\u6bd2\u7406\u5b66\u7814\u7a76\uff0c\u6211\u4eec\u7684\u4e34\u5e8a\u8bd5\u9a8c\u60a3\u8005\u7528\u4e86\u6211\u4eec\u7684\u836f\u7269\uff0c\u6211\u4eec\u5e0c\u671b\u80fd\u4fdd\u62a4\u4ed6\u4eec\u2026\u2026\u201d\u4ed6\u7528\u79d1\u5b66\u672f\u8bed\u5217\u51fa\u6709\u5173\u5b89\u5168\u6027\u7684\u95ee\u9898\uff0c\u201c\u6211\u8ba4\u4e3a\u8fd9\u662f\u4e00\u4ef6\u79d1\u5b66\u9053\u5fb7\u95ee\u9898\uff0c\u79d1\u5b66\u5bb6\u4eec\u4ea4\u6362\u6838\u5fc3\u4fe1\u5fc3\uff0c\u5c24\u5176\u662f\u533b\u5b66\u5e94\u7528\u95ee\u9898\u201d\u3002<\/p>\n

\u74e6\u6770\u6d1b\u65af\u8ba4\u4e3a\u8fd9\u79cd\u76f4\u63a5\u7684\u79d1\u5b66\u4fe1\u606f\u4ea4\u6d41\u5e94\u8be5\u4f1a\u6210\u529f\u3002\u201c\u9ed8\u514b\u4e0e\u65e5\u672c\u7684\u5236\u836f\u754c\u6709\u5bc6\u5207\u8054\u7cfb\uff0c\u7b2c\u4e8c\u6b21\u4e16\u754c\u5927\u6218\u7ed3\u675f\u540e\u4e0d\u4e45\uff0c\u9ed8\u514b\u66fe\u5e2e\u52a9\u65e5\u672c\u5236\u836f\u754c\u83b7\u5f97\u5236\u9020\u94fe\u9709\u7d20\u7684\u751f\u4ea7\u6280\u672f\uff0c\u5bf9\u5e94\u5bf9\u5f53\u65f6\u5728\u65e5\u672c\u6d41\u884c\u7684\u80ba\u7ed3\u6838\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u9ed8\u514b\u4e0e\u65e5\u672c\u4e2d\u578b\u5236\u836f\u516c\u53f8\u2018Banyu\u2019\u5efa\u7acb\u4e86\u5bc6\u5207\u7684\u5de5\u4f5c\u5173\u7cfb\u2026\u2026\u201d<\/p>\n

\u4f46\u662f\uff0c\u65e5\u672c\u65b9\u9762\u6ca1\u6709\u56de\u590d\u3002\u74e6\u6770\u6d1b\u65af\u51b3\u5b9a\u4eb2\u81ea\u5230\u65e5\u672c\uff0c\u4e0e\u2018\u4e09\u5171\u2019\u8fdb\u884c\u5546\u52a1\u4f1a\u8bae\u3002\u4ed6\u8bf4\uff1a\u201c\u5982\u679c\u4f60\u4eec\u5e2e\u52a9\u6211\u4eec\u89e3\u51b3\u4e86\u8fd9\u4e2a\u95ee\u9898\uff0c\u6211\u4eec\u5c06\u4e0e\u4f60\u4eec\u5206\u4eab\u6d1b\u4f10\u4ed6\u6c40\u5728\u65e5\u672c\u7684\u5546\u52a1\uff0c\u5728\u4f60\u4eec\u51c6\u5907\u597d\u65f6\uff0c\u4e5f\u80fd\u548c\u6211\u4eec\u5206\u4eab\u4f60\u4eec\u7684\u7b2c\u4e8c\u4ee3\u4ea7\u54c1\u3002\u201d<\/p>\n

\u7136\u800c\uff0c\u201c\u4e09\u5171\u201d\u8d1f\u8d23\u4eba\u7b11\u7740\u8868\u793a\uff0c\u4ed6\u4eec\u5e0c\u671b\u4e0e\u9ed8\u514b\u5408\u4f5c\uff0c\u4f46\u5176\u4ed6\u4eba\u53cd\u5bf9\u4ea4\u6362\u6570\u636e\u3002<\/p>\n

\u201c\u8fd9\u6b21\u65e5\u672c\u4e4b\u884c\uff0c\u6211\u6ca1\u6709\u529e\u6cd5\u5c31\u4ed6\u4eec\u7684\u53d1\u73b0\u8fdb\u884c\u79d1\u5b66\u8ba8\u8bba\u3002\u4ed6\u4eec\u7684\u884c\u653f\u5f53\u5c40\u5c06\u8fd9\u4e2a\u95ee\u9898\u5f53\u4f5c\u662f\u516c\u53f8\u95f4\u7684\u7ade\u4e89\uff0c\u800c\u4e0d\u662f\u836f\u7269\u53d1\u73b0\u8fc7\u7a0b\u4e2d\u7684\u533b\u5b66\u95ee\u9898\u3002\u6211\u975e\u5e38\u751f\u6c14\uff0c\u4f46\u65e0\u529b\u6539\u53d8\u8fd9\u79cd\u7d27\u5f20\u5173\u7cfb\u3002\u201d<\/p>\n

\u8fd9\u662f\u4e00\u4e2a\u5de6\u53f3\u4e3a\u96be\u7684\u56f0\u5883\u3002\u4e00\u65b9\u9762\uff0c\u9ed8\u514b\u7684\u6bd2\u7406\u8bd5\u9a8c\u663e\u793a\uff1a\u6ca1\u6709\u8bc1\u636e\u663e\u793a\u6d1b\u4f10\u4ed6\u6c40\u6709\u95ee\u9898\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u65e5\u672c\u65b9\u9762\u7684\u8c23\u8a00\u4e0d\u80fd\u83b7\u4ee5\u8bc1\u5b9e\u3002<\/p>\n

\u201c\u6211\u4eec\u60ac\u5728\u534a\u7a7a\u4e2d\uff0c\u65e0\u6cd5\u7ee7\u7eed\u63a8\u8fdb\u6d1b\u4f10\u4ed6\u6c40\u7684\u7814\u7a76\u2026\u2026\u6211\u5f00\u59cb\u6566\u4fc3\u751f\u7269\u5b66\u5bb6\u4eec\u5168\u529b\u5bfb\u627e\u6d1b\u4f10\u4ed6\u6c40\u7684\u66ff\u4ee3\u7269\uff0c\u6211\u4e0d\u5728\u4e4e\u8c01\u4f1a\u4f18\u5148\u83b7\u80dc\uff0c\u6211\u53ea\u5e0c\u671b\u8d62\u5f97\u8fd9\u573a\u5bf9\u4ed8\u80c6\u56fa\u9187\u6218\u6597\u7684\u80dc\u5229\u3002\u201d\u74e6\u6770\u6d1b\u65af\u5728\u4ed6\u7684\u4e66\u4e2d\u5199\u9053\u3002<\/p>\n

\u4e03\u3001\u91cd\u78c5\u70b8\u5f39<\/strong><\/p>\n

\u201c\u7f57\u4f0a\uff0c\u9ad8\u80c6\u56fa\u9187\u6b63\u5728\u6740\u6b7b\u4eba\u4eec\u2026\u2026\u201d<\/p>\n

1982\u5e74\u7684\u4e00\u5929\uff0c\u4f5c\u4e3a\u9ed8\u514b\u5916\u90e8\u987e\u95ee\uff0c\u4e09\u4f4d\u6765\u81ea\u4fc4\u52d2\u5188\u548c\u8fbe\u90a3\u65af\u7684\u5fc3\u810f\u75c5\u5b66\u533b\u5b66\u4e13\u5bb6\u5230\u65b0\u6cfd\u897f\u5dde\u9ed8\u514b\u603b\u90e8\u8bbf\u95ee\u3002<\/p>\n

\u4e09\u4f4d\u4e13\u5bb6\u4e5f\u5728\u4e34\u5e8a\u6cbb\u7597\u4e25\u91cd\u5fc3\u8840\u7ba1\u75c5\u4eba\u3002\u60a3\u8005\u7684\u51a0\u72b6\u8840\u7ba1\u88ab\u80c6\u56fa\u9187\u548c\u8102\u80aa\u6591\u5757\u963b\u585e\uff0c\u73b0\u6709\u7684\u6cbb\u7597\u65b9\u6cd5\u65e0\u6cd5\u5bf9\u4ed8\u60a3\u8005\u6301\u7eed\u5347\u9ad8\u7684\u80c6\u56fa\u9187\u3002\u4ed6\u4eec\u4e00\u81f4\u8feb\u5207\u8981\u6c42\uff1a\u201c\u7f57\u4f0a\uff0c\u6d1b\u4f10\u4ed6\u6c40\u662f\u4e34\u5e8a\u4e0a\u6709\u5f88\u597d\u7684\u6548\u679c\uff0c\u4e3a\u4ec0\u4e48\u4e0d\u8ba9\u6211\u4eec\u5728\u90e8\u5206\u9ad8\u5371\u60a3\u8005\u8eab\u4e0a\u6cbb\u7597\u4f7f\u7528\uff1f\u201d<\/p>\n

\u201c\u4f5c\u4e3a\u66fe\u7ecf\u7684\u4e34\u5e8a\u533b\u751f\uff0c\u6211\u9053\u4ed6\u4eec\u662f\u5bf9\u7684\uff0c\u201d\u74e6\u6770\u6d1b\u65af\u8bf4\uff0c\u201c\u4f5c\u4e3a\u9ed8\u514b\u7814\u53d1\u90e8\u8d1f\u8d23\u4eba\uff0c\u6211\u4e5f\u5fc3\u52a8\u4f46\u6709\u72b9\u8c6b\uff0c\u73b0\u6709\u7684\u533b\u5b66\u8bc1\u636e\u63ed\u793a\u4e86\u9ad8\u6c34\u5e73\u7684\u80c6\u56fa\u9187\u662f\u5fc3\u810f\u75be\u75c5\u7684\u4e3b\u8981\u8bf1\u56e0\uff0c\u6211\u4e5f\u77e5\u9053\u4ed6\u4eec\u901a\u8fc7\u836f\u7269\u6cbb\u7597\u548c\u996e\u98df\u63a7\u5236\u4e5f\u65e0\u6cd5\u5c06\u60a3\u8005\u7684\u80c6\u56fa\u9187\u6c34\u5e73\u964d\u4f4e\u5230\u5b89\u5168\u8303\u56f4\u3002\u6709\u592a\u591a\u8fd9\u6837\u7684\u75c5\u4f8b\uff0c\u52a8\u8109\u88ab\u6591\u5757\u963b\u585e\u7684\u60a3\u8005\u968f\u65f6\u9762\u4e34\u5a01\u80c1\u751f\u547d\u7684\u5fc3\u529b\u8870\u7aed\u2026\u2026\u201d<\/p>\n

\u74e6\u6770\u6d1b\u65af\u5f00\u59cb\u7075\u9b42\u7684\u62f7\u95ee\u3002<\/p>\n

\u201c\u6211\u4e0d\u786e\u8bc1\u6765\u81ea\u65e5\u672c\u65b9\u9762\u7684\u62a5\u544a\uff0c\u4f46\u6211\u4e0d\u80fd\u5ffd\u7565\u5b83\u4eec\uff0c\u56e0\u6b64\uff0c\u6211\u4eec\u542f\u52a8\u5927\u89c4\u6a21\u6a21\u5f0f\u52a8\u7269\u6bd2\u7406\u5b66\u5b9e\u9a8c\uff0c\u5bfb\u627e\u6d1b\u4f10\u4ed6\u6c40\u5f15\u53d1\u80bf\u7624\u7684\u8bc1\u636e\uff0c\u4f46\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u6ca1\u6709\u663e\u793a\u6709\u8fd9\u7c7b\u95ee\u9898\uff0c\u5176\u4e2d\u4e00\u4e2a\u4e3a\u671f\u4e24\u5e74\u7684\u5b9e\u9a8c\u5373\u5c06\u7ed3\u675f\uff0c\u4f46\u6211\u4eec\u5728\u624b\u7684\u8bc1\u636e\u663e\u793a\u6d1b\u4f10\u4ed6\u6c40\u662f\u5b89\u5168\u7684\u3002\u4e09\u4f4d\u987e\u95ee\u7684\u5efa\u8bae\u8feb\u4f7f\u6211\u4eec\u6743\u8861\u65b0\u7684\u5229\u5f0a\uff1a\u7528\u6d1b\u4f10\u4ed6\u6c40\u964d\u4f4e\u9ad8\u5371\u60a3\u8005\u80c6\u56fa\u9187\u6c34\u5e73\u7684\u76ca\u5904\uff0c\u662f\u5426\u5927\u4e8e\u53ef\u80fd\u7684\u526f\u4f5c\u7528\uff1f\u201d<\/p>\n

1983\u5e7411\u6708\uff0c\u74e6\u6770\u6d1b\u65af\u548c\u9ed8\u514b\u540c\u4e8b\u3001\u5916\u90e8\u987e\u95ee\u7efc\u5408\u8ba8\u8bba\u4e86\u76f8\u5173\u7684\u7ed3\u679c\u3001\u65e5\u672c\u5eb7\u67cf\u6c40\u7684\u4fe1\u606f\u3002\u5927\u5bb6\u540c\u610f\uff1a\u91cd\u542f\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n

\u9ed8\u514b\u5411FDA\u9012\u4ea4\u4e86\u91cd\u542f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7533\u8bf7\uff0cFDA\u540c\u610f\u5bf9\u9ad8\u5371\u60a3\u8005\u7684\u8bd5\u9a8c\u3002<\/p>\n

\u8fd9\u662f\u6d1b\u4f10\u4ed6\u6c40\u8d77\u6b7b\u56de\u751f\u7684\u65f6\u523b\u3002<\/p>\n

\u72c2\u559c\u4e2d\uff0c\u7814\u53d1\u56e2\u961f\u7acb\u5373\u5f00\u542f\u7b2c\u4e8c\u8f6e\u4e34\u5e8a\u8bd5\u9a8c\u3002\u963f\u5c14\u4f2f\u8328\u8bf4\uff1a\u201c\u6211\u77e5\u9053\u4f60\u4eec\u4e0d\u4f1a\u5728\u6211\u6700\u7231\u7684\u5206\u5b50\u4e0a\u627e\u51fa\u4ec0\u4e48\u95ee\u9898\u3002\u201d<\/p>\n

\u8001\u5929\u7ed9\u8fd9\u652f\u4e0d\u5c48\u4e0d\u6320\u7684\u56e2\u961f\u4ee5\u53cc\u91cd\u5609\u5956\u3002\u5728\u6d1b\u4f10\u4ed6\u6c40\u9760\u8fb9\u7ad9\u65f6\uff0c\u74e6\u6770\u6d1b\u65af\u7684\u6307\u5bfc\u9ed8\u514b\u7814\u7a76\u56e2\u961f\u52aa\u529b\u5bfb\u627e\u53e6\u4e00\u79cd\u65e0\u6bd2\u6027\u7684\u5206\u5b50\uff1b\u5f53\u6d1b\u4f10\u4ed6\u6c40\u91cd\u542f\u4e34\u5e8a\u8bd5\u9a8c\u65f6\uff0c\u5316\u5b66\u5bb6\u9c8d\u52c3\u00b7\u53f2\u5bc6\u65af\uff08Bob Smith\uff09\u7684\u56e2\u961f\u53d1\u73b0\u4e86\u7b2c\u4e8c\u79cdHMG-CoA\u8fd8\u539f\u9176\u6291\u5236\u5242\u2014\u2014\u8f9b\u4f10\u4ed6\u6c40\uff08simvastatin\uff09\uff0c\u5e76\u7814\u5236\u6210\u836f\u7269Zocor\u3002\u4e0e\u6b64\u540c\u65f6\uff0cNIH\u5fc3\u80ba\u7814\u7a76\u6240\u53d1\u8868\u4e86\u4e00\u7bc7\u91cc\u7a0b\u7891\u5f0f\u7684\u8bba\u6587\uff1a\u63ed\u793a\u80c6\u56fa\u9187\u6c34\u5e73\u4e0e\u51a0\u5fc3\u75c5\u7684\u5173\u7cfb\u3002<\/p>\n

\u201c\u8fd9\u4e00\u53d1\u73b0\u8bc1\u5b9e\u4e86\u6211\u4eec\u957f\u671f\u6000\u7591\u7684\u57fa\u4e8e\u65e9\u671f\u6d41\u884c\u75c5\u5b66\u6570\u636e\u7684\u63a8\u8bba\u3002\u8840\u6db2\u4e2d\u80c6\u56fa\u9187\u503c\u6bcf\u964d\u4e00\u4e2a\u767e\u5206\u70b9\uff0c\u5fc3\u810f\u75c5\u7684\u6b7b\u4ea1\u7387\u51cf\u5c11\u4e24\u4e2a\u767e\u5206\u70b9\u3002\u201d\u74e6\u6770\u6d1b\u65af\u8bf4\u3002<\/p>\n

\u597d\u6d88\u606f\u4e0d\u65ad\uff1a\u7edd\u5927\u591a\u6570\u9ad8\u5371\u60a3\u8005\uff08\u8840\u6db2\u4e2d\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u8d28\u6c34\u5e73\u8d85\u9ad8\uff09\u7684\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff1a\u80c6\u56fa\u9187\u6c34\u5e73\u7684\u4e0b\u964d\u91cf\u4e3a\uff1a18%-34%\uff0c\u4e0d\u4ec5\u5982\u6b64\uff0c\u80c6\u56fa\u9187\u4e2d\u7684\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\u8d28\uff08\u597d\u80c6\u56fa\u9187\uff09\u7684\u6c34\u5e73\u5374\u5728\u63d0\u9ad8\uff1b\u800c\u4e14\uff0c\u8840\u6db2\u4e2d\u7684\u7518\u6cb9\u4e09\u9178\u916f\u7684\u6c34\u5e73\u4e5f\u4e0b\u964d\u4e86\u3002<\/p>\n

\u74e6\u6770\u6d1b\u65af\u8bf4\uff1a\u6ca1\u6709\u201c\u5b8c\u7f8e\u836f\u7269\u201d\uff0c\u6240\u6709\u7684\u836f\u7269\u90fd\u6709\u526f\u4f5c\u7528\uff0c\u4f46\u6d1b\u4f10\u4ed6\u6c40\u5374\u5982\u6b64\u4e0e\u4f17\u4e0d\u540c\uff0c\u5b83\u662f\u4e00\u79cd\u201c\u795e\u5947\u7684\u836f\u7269\u201d\u3002\u6bcf\u5929\u53ea\u670d\u7528\u4e00\u7247\uff0c\u8bb8\u591a\u7684\u60a3\u8005\u5c06\u80fd\u5c06\u80c6\u56fa\u9187\u6c34\u5e73\u964d\u5230\u5b89\u5168\u503c\u8303\u56f4\u5185\uff0c\u800c\u4e14\u53ea\u51fa\u73b0\u5f88\u5c0f\u7684\u526f\u4f5c\u7528\uff0c\u8fd9\u4e9b\u526f\u4f5c\u7528\u4f1a\u5f88\u5feb\u6d88\u5931\uff0c\u53ea\u67092%\u7684\u8bd5\u9a8c\u8005\u51fa\u73b0\u809d\u810f\u9176\u6c34\u5e73\u7684\u63d0\u9ad8\uff0c\u4f46\u8fd9\u662f\u56e0\u4e3a\u4ed6\u4eec\u670d\u7528\u4e86\u9ad8\u5242\u91cf\u7684\u836f\u3002\u6700\u7ec8\u7684\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff1a\u5728\u663e\u8457\u964d\u4f4e\u51a0\u72b6\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98ce\u9669\u56e0\u7d20\u65f6\uff0c\u6d1b\u4f10\u4ed6\u6c40\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n

1987\u5e74\uff0c\u7ecf\u8fc7\u6f2b\u957f\u7684\u5ba1\u67e5\uff0cFDA\u6279\u51c6\u6d1b\u4f10\u4ed6\u6c40\u4e0a\u5e02\u3002<\/p>\n

\u6d1b\u4f10\u4ed6\u6c40\u662f\u4eba\u7c7b\u5386\u53f2\u4e0a\u4e00\u9879\u4f1f\u5927\u7684\u533b\u5b66\u7a81\u7834\u3002\u201c\u5728\u83b7\u5f97FDA\u6279\u51c6\u4e4b\u65f6\uff0c\u7f8e\u56fd\u6709\u4e00\u534a\u4ee5\u4e0a\u7684\u4e2d\u5e74\u4eba\u80c6\u56fa\u9187\u503c\u6c34\u5e73\u9ad8\u4e8e\u6b63\u5e38\u503c\uff0c\u6d1b\u4f10\u4ed6\u6c40\u5c06\u51cf\u5c11\u4ed6\u4eec\u60a3\u5fc3\u810f\u75be\u75c5\u7684\u98ce\u9669\uff0c\u6211\u4eec\u5c06\u63d0\u9ad8\u51e0\u767e\u4e07\u4eba\u7684\u751f\u6d3b\u8d28\u91cf\uff0c\u8fd9\u662f\u6211\u4eec\u7684\u751f\u547d\u6700\u4e30\u5bcc\u7684\u65f6\u523b\u3002\u201d \u74e6\u6770\u6d1b\u65af\u8bf4\u3002<\/p>\n

\u5728FDA\u6279\u51c6\u4e4b\u540e\uff0c\u9ed8\u514b\u542f\u52a8\u4e86\u4e00\u4e2a\u4e3a\u671f\u4e94\u5e74\u3001\u8ddf\u8e2a4400\u4f4d\u60a3\u8005\u7684\u9879\u76ee\uff0c\u7814\u7a76\u7b2c\u4e8c\u79cdHMG-CoA\u8fd8\u539f\u9176\u6291\u5236\u5242Zocor\u3002\u6240\u6709\u53c2\u4e0e\u8bd5\u9a8c\u8005\u5747\u60a3\u6709\u51a0\u5fc3\u75c5\uff0c\u7ecf\u5386\u8fc7\u5fc3\u529b\u8870\u7aed\u6216\u80f8\u90e8\u5de8\u75db\uff0c\u540c\u65f6\u8840\u6db2\u4e2d\u7684\u7518\u6cb9\u4e09\u9178\u916f\u6c34\u5e73\u8d85\u6807\u3002<\/p>\n

\u201c\u6cbb\u7597\u6548\u679c\u4ee4\u6211\u4eec\u5bf9\u2018\u9ed8\u514b\u7597\u6cd5\u2019\u611f\u52a8\u9707\u60ca\uff1a\u8fd9\u79cd\u9776\u5411\u6cbb\u7597\u836f\u7269\u5c06\u5fc3\u810f\u75c5\u6b7b\u4ea1\u7387\u964d\u4f4e\u4e8630%\uff01\u7531\u51a0\u72b6\u52a8\u8109\u963b\u585e\u5bfc\u81f4\u7684\u6b7b\u4ea1\u7387\u964d\u4f4e42%\uff1b\u51a0\u72b6\u52a8\u8109\u5916\u79d1\u624b\u672f\u51cf\u5c1137%\u3002\u6b64\u5916\uff0c\u8fd9\u79cd\u836f\u7684\u4f7f\u7528\u964d\u4f4e\u4e86\u5065\u5eb7\u62a4\u7406\u7684\u6210\u672c\u3002\u201d\u8fd9\u4e9b\u6570\u636e\u4ee4\u74e6\u6770\u6d1b\u65af\u6fc0\u52a8\u4e0d\u5df2\uff0c\u751a\u81f3\u5f15\u8d77\u4e86\u5065\u5eb7\u7ecf\u6d4e\u5b66\u5bb6\u7684\u5173\u6ce8\u3002<\/p>\n

\u4ece\u57fa\u7840\u7814\u7a76\u53d1\u73b0\u3001\u4e34\u5e8a\u8bd5\u9a8c\u3001\u5b9e\u9645\u4f7f\u7528\u6548\u679c\u7684\u8c03\u67e5\uff0c\u5206\u5b50\u9776\u5411\u836f\u7269\u660e\u663e\u964d\u4f4e\u80c6\u56fa\u9187\u6c34\u5e73\u548c\u76f8\u5173\u6b7b\u4ea1\u7387\uff0c\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u63d0\u9ad8\u3001\u533b\u7597\u6210\u672c\u663e\u8457\u51cf\u5c11\uff1b\u4ece\u6cbb\u7597\u6548\u679c\u5230\u5e02\u573a\u4ef7\u503c\uff0c\u6d1b\u4f10\u4ed6\u6c40\u548c\u65af\u4f10\u4ed6\u6c40\u51fa\u73b0\u4e86\u201c\u6eda\u96ea\u7403\u6548\u5e94\u201d\uff0c\u8fd9\u4e24\u79cd\u836f\u7269\u5360\u636e\u7f8e\u56fd\u964d\u80c6\u56fa\u9187\u836f\u7269\u7684\u534a\u58c1\u6c5f\u5c71\uff0c\u5e76\u8fdb\u516530\u591a\u4e2a\u56fd\u5bb6\u7684\u5e02\u573a\uff0c\u6210\u4e3a\u9ed8\u514b\u7b2c\u4e00\u4e2a\u9500\u552e\u8d85\u8fc710\u4ebf\u7f8e\u5143\u7684\u91cd\u78c5\u70b8\u5f39\uff08Blockbusters\uff09\u836f\u7269\u3002<\/p>\n

\u201c\u5728\u7f8e\u56fd\u548c\u4e16\u754c\u4e0a\uff0c\u9776\u5411\u5206\u5b50\u836f\u2018\u6d1b\u4f10\u4ed6\u6c40\u2019\u7684\u6210\u529f\u4e0d\u4ec5\u662f\u533b\u5b66\u754c\u3001\u800c\u4e14\u4e5f\u662f\u9ed8\u514b\u3001\u5236\u836f\u754c\u3001\u5de5\u4e1a\u754c\u3001\u751a\u81f3\u6295\u8d44\u754c\u7684\u5927\u65b0\u95fb\u3002\u201d<\/p>\n

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